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The U.S. Department of Health and Human Services today announced new efforts to support President Donald J. Trump’s Genesis Mission, aligning expertise and capabilities across the department to harness artificial intelligence in support of biomedical research through what is now being called the Bio Genesis Mission HHS initiative.
Why HHS Is Launching the Bio Genesis Mission
These efforts advance a key priority of Secretary Robert F. Kennedy Jr. to address the nation’s chronic disease epidemic, a prime focus of the MAHA Strategy unveiled by the Trump administration in September 2025. “America will lead the next generation of medical discovery by harnessing the power of artificial intelligence,” said Kennedy. “We are mobilizing the nation’s best researchers to uncover the root causes of chronic disease, accelerate lifesaving breakthroughs, and help Make America Healthy Again.”
A Series of National Science Challenges
Working in partnership with the White House Office of Science and Technology Policy, HHS will launch a series of National Science and Technology Challenges that invite America’s scientific community to apply next-generation artificial intelligence to some of the nation’s most urgent health challenges. The flagship challenge will focus on identifying the root causes of chronic disease; additional challenges will accelerate research on pediatric cancer and transform drug discovery and development.
The Origins of the Bio Genesis Mission HHS Effort
Launched by President Trump in November 2025, the Genesis Mission will usher in a new era of American scientific discovery by harnessing artificial intelligence, advanced computing, and the nation’s unparalleled research enterprise to solve some of humanity’s greatest challenges. As the Genesis Mission platform is developed, HHS will help shape its biomedical capabilities by contributing diverse scientific datasets and rallying researchers to explore how AI can accelerate breakthroughs.
The Government-Wide Centerpiece
The centerpiece of HHS’s participation in the Genesis Mission is a government-wide effort, the NIH-led Bio Genesis Mission, which will use artificial intelligence, advanced computing, and cross-sector partnerships to modernize the biomedical research ecosystem and cut in half the time it takes for scientific discoveries to reach patients.
How the Bio Genesis Mission HHS Initiative Will Work
By applying advanced AI tools to large and complex datasets with appropriate security and privacy protection spanning multiple scientific disciplines, researchers will be challenged to uncover previously unseen patterns, generate new hypotheses, and identify promising pathways for prevention and treatment.
NIH Director’s Perspective on the Mission
“Patients living with cancer, chronic disease, and rare conditions cannot afford to wait decades for scientific discoveries to reach them,” said NIH Director Dr. Jay Bhattacharya. “Through the Bio Genesis Mission, we are harnessing artificial intelligence and advanced computing to help researchers uncover the root causes of disease, accelerate the development of new treatments, and build a biomedical research ecosystem that delivers lifesaving innovations to patients faster, while upholding the rigorous scientific standards and responsible stewardship that earn the public’s trust.”
Which Agencies Are Contributing to the Bio Genesis Mission HHS Effort
HHS agencies, including NIH, FDA, and ARPA-H, will contribute a broad range of scientific resources to support these efforts, including biomedical research, genomics, public health, and safety data. These rich datasets, combined with the Genesis Mission’s advanced computing capabilities, will help researchers analyze information at a scale and speed that has never before been possible.
Additional Research Challenges Beyond Chronic Disease
In addition to the chronic disease challenge, HHS will launch research challenges focused on accelerating breakthroughs in pediatric cancer research by identifying new biological insights and therapeutic opportunities, and transforming drug discovery and development by using AI to shorten development timelines, identify promising therapeutic targets, and bring safe, effective treatments to patients faster.
What the Bio Genesis Mission HHS Effort Aims to Demonstrate
Together, these efforts will help demonstrate how artificial intelligence can strengthen America’s biomedical research enterprise by enabling scientists to generate hypotheses more rapidly, analyze enormous volumes of data, and accelerate discoveries that otherwise could take years using traditional approaches.
What This Means for the Future of Biomedical Research
By combining America’s world-class researchers with cutting-edge AI and computing infrastructure, the department aims to unlock discoveries that improve health, reduce the burden of chronic disease, and position the United States as the global leader in AI-driven biomedical innovation. As the Bio Genesis Mission HHS challenges launch and researchers begin applying AI to these targeted problem areas, the coming months and years will reveal whether this cross-agency approach can meaningfully compress the traditionally long timeline between scientific discovery and patient benefit.
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